Disorder of Coagulation Cascade
DISORDERS OF COAGULATION CASCADE (BLEEDING DISORDERS)
INTERPRETATION OF LABORATORY PARAMETERS
FACTOR DEFICIENT | BT | PTT | PT | TT |
VII | N | N | A | N |
VIII, IX, XI, XII | N | A | N | N |
Von-Willebrand factor | A | A | N | N |
Dysfibrinogenemia | N | A | A | A |
II, V, X. | N | A | A | N |
XIII | N | N | N | N |
BT= Bleeding Time, PTT= Partial Thromboplastin Time, PT= Prothrombin Time, TT= Thromboplastin Time N=Normal, A= Abnormal.
To differentiate between IX and VIII, a PTT should be repeated after trying correction with AGED and ADSORBED sera. If AGED serum corrects a PTT, it is a factor IX deficiency. If ADSORBED serum corrects a PTT, it is a factor VIII deficiency.
ANTICOAGULATION
Therapeutic goals for anticoagulation:
INDICATION | INR |
Venous thromboembolism Pulmonary embolism Previous systemic embolism Atrial fibrillation Bioprosthetic heart valves |
2-3 |
Mechanical heart valves | 2.5-3.5 |
Antiphilosophical antibody with thrombosis |
3-4 |
Correction of prolonged INR:
References
No references available