Introduction

A form of spondyloarthritis, is a chronic, inflammatory arthritis and autoimmune It mainly affects joints in the spine and the sacroiliac joint in the pelvis, and can cause eventual fusion of the spine.

Definition

The typical patient is a young male, aged 20-40, however the condition also presents in females. The condition is known to be hereditary. Symptoms of the disease first appear, on average, at age 23 years. These first symptoms are typically chronic pain and stiffness in the middle part of the spine or sometimes the entire spine, often with pain referred to one other buttock or the back of thigh from the sacroiliac joint.

Incidence of condition in our country

Three men are diagnosed with AS for every one woman; the overall prevalence is 0.25%. Many rheumatologists believe the number of women with AS is underdiagnosed, as most women tend to experience milder symptoms.

Differential diagnosis

Differential diagnosis of Ankylosing Spondylitis include

·                 Rheumatoid Arthritis

·                 Other Spondylo arhtropathies

Prevention and counselling

As no direct cause for the disease has been identified the preventive measures could not be established.

Patient needs to be counselled regarding the chronic nature of the disease and need for regular treatment, possible complications and possible treatment options and chances of improvement.

SITUATION 1

·                 Clinical diagnosis: chronic pain and stiffness in the middle part of the spine or sometimes the entire spine, often with pain referred to one or other buttock or the back of thigh from the sacroiliac joint. Post inactivity stiffness and morning stiffness. In 40% of cases, ankylosing spondylitis is associated with an inflammation of the eye (iritis and uveitis), causing redness, eye pain, vision loss, floaters and photophobia. This is thought to be due to the association these two conditions have with inheritance of HLA-B27. Other common symptoms are generalized fatigue and sometimes nausea.

·                 Investigations:

•                          XRay

•                          CT Scan

•                          MRI

•                          Complete Blood Picture

•                          ESR

•                          CRP

•                          Liver function test

•                          Renal function test

•                          HLA B2 7

•                          In a patient complaining of back pain of more than 12 weeks duration:

•                          Morning stiffness of> 30 minutes

•                          Improvement in back pain with exercise but not with rest.

•                          Awakening because of back pain during the second half of the night only.

•                          Alternating buttock pain

•                          Peripheral assymetrical large joint involvement

•                          Plain X Ray showing features of sacroilitis.

•                          Absence of RA factor.

Any 2 out of first four criteria strongly indicate presence of Ankylosing Spondylitis even in the absence of xray and lab investigations.

Treatment:

Standard Operating Procedure

·       In Patient:

•   Surgery (Joint Replacement for hip and knee)

•        Out Patient:

•   NSAIDS: First line therapy to relieve symptoms.

DMARDs

Such as cyclosporin, methotrexate, sulfasalazine, and corticosteroids, used to reduce the immune system response through immuriosuppression DMARDs are useful only for peripheral arthritis & not for axial skeleton involvement.   -

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Blockers (antagonists) such as etanercept, infliximab, golimumab and adalimumab (also known as biologics), are indicated for the treatment of and are effective immunosuppressants as in other autoimmune diseases.

•           Physical Therapy - Patients to be encouraged to undertake active and passive range of motion exercises for all joints to maintain and prevent the progression of loss of mobility. Deep breathing exercises (Pranayaam) should be promoted to improve chest function.

•           Day Care: Injectable medications